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KMID : 0604520150410040383
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 4 p.383 ~ p.389
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Inhibitory Effect of Ginkgo biloba Extracts on Melanin Biosynthesis
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Kim Yoon-Suk
Lee Young-Hwa
Lee Jin-Young
Yi Yong-Sub
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Abstract
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In this study, we investigated the inhibitory effect on melanin synthesis of Ginkgo biloba seed oil. The results showed 9.96% inhibitory effect scavenging activity on DPPH and showed a value of 1.33 mM of FeSO4 at a concentration of 0.06% in DMSO by using FRAP assay. G. biloba seed oil inhibited tyrosinase activity up tp 37.72% and suppressed the biosynthesis melanin up to 48.02% at 0.06% in B16/F10 mouse melanoma cell. In G. biloba seed oil treated group tyrosinase, TRP-1, TRP-2 and MITF gen expression levels significantly decreased compared to the contral group at a concentration of 0.04% and 0.06%. In conclusion, these results indicated that G. biloba seed oil extract have a good antimelanogenetic effects.
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KEYWORD
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Ginkgo biloba, DPPH activity, melanin, oil, antimelanogenetic
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